
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TWIRLA | Agile Therapeutics | N-204017 RX | 2020-02-14 | 1 products, RLD, RS |
| BALCOLTRA | Avion Pharmaceuticals | N-208612 RX | 2018-01-09 | 1 products, RLD, RS |
| TYBLUME | Exeltis | N-209405 RX | 2020-03-30 | 1 products, RLD, RS |
| LOSEASONIQUE | Teva | N-022262 RX | 2008-10-24 | 1 products |
| QUARTETTE | Teva | N-204061 RX | 2013-03-28 | 1 products, RLD, RS |
| SEASONALE | Teva | N-021544 RX | 2003-09-05 | 1 products, RLD, RS |
| SEASONIQUE | Teva | N-021840 RX | 2006-05-25 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CYCLESSA | Aspen Global | N-021090 RX | 2000-12-20 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRI-NORINYL 28-DAY | Dr Reddys Laboratories | N-018977 RX | 1984-04-13 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ORTHO CYCLEN-21 | Johnson & Johnson | N-019653 DISCN | 1989-12-29 | 1 products |
| ORTHO CYCLEN-28 | Johnson & Johnson | N-019653 DISCN | 1989-12-29 | 1 products, RLD |
| ORTHO TRI-CYCLEN | Johnson & Johnson | N-019697 DISCN | 1992-07-03 | 2 products |
| ORTHO TRI-CYCLEN LO | Johnson & Johnson | N-021241 DISCN | 2002-08-22 | 1 products, RLD |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ORTHO EVRA | Johnson & Johnson | N-021180 DISCN | 2001-11-20 | 1 products, RLD |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LYNORAL | Organon | N-005490 DISCN | 1982-01-01 | 2 products |
| FEMINONE | Pharmacia & Upjohn | N-016649 DISCN | 1982-01-01 | 1 products |
| ESTINYL | Merck & Co | N-005292 DISCN | 1982-01-01 | 3 products |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DEMULEN 1/50-21 | G.D. Searle | N-016927 DISCN | 1982-01-01 | 1 products |
| DEMULEN 1/50-28 | G.D. Searle | N-016936 DISCN | 1982-01-01 | 1 products |
| DEMULEN 1/35-28 | G.D. Searle | N-018160 DISCN | 1982-01-01 | 1 products |
| DEMULEN 1/35-21 | G.D. Searle | N-018168 DISCN | 1982-01-01 | 1 products |
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ANNOVERA | Mayne Group | N-209627 RX | 2018-08-10 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
|---|---|---|
| afirmelle | ANDA | 2025-08-01 |
| altavera | ANDA | 2023-03-02 |
| alyacen 1/35 | ANDA | 2024-05-07 |
| alyacen 1/35 alyacen 7/7/7 | ANDA | 2017-09-08 |
| alyacen 7/7/7 | ANDA | 2023-06-07 |
| amethia | ANDA | 2024-03-01 |
| amethyst | ANDA | 2022-01-31 |
| annovera | New Drug Application | 2025-04-23 |
| apri | ANDA | 2024-06-12 |
| aranelle | ANDA | 2023-01-31 |
Expiration | Code | ||
|---|---|---|---|
ETHINYL ESTRADIOL / SEGESTERONE ACETATE, ANNOVERA, MAYNE PHARMA | |||
| 2023-08-10 | NCE | ||
ETHINYL ESTRADIOL / LEVONORGESTREL, TYBLUME, EXELTIS USA INC | |||
| 2023-03-30 | NDF | ||
ETHINYL ESTRADIOL / LEVONORGESTREL, TWIRLA, AGILE | |||
| 2023-02-14 | NP | ||
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Ethinyl Estradiol / Segesterone Acetate, Annovera, Mayne Pharma | |||
| 10918649 | 2039-06-21 | DP | |
| 10925882 | 2039-06-21 | DP | |
| 10940157 | 2039-06-21 | DP | |
| 11529308 | 2039-06-21 | DP | |
| 10632066 | 2039-02-01 | U-2786, U-2787 | |
| 10765628 | 2039-02-01 | U-2786, U-2787 | |
| 10780047 | 2039-02-01 | U-2786, U-2787 | |
| Drospirenone / Ethinyl Estradiol / Levomefolate Calcium, Beyaz, Bayer Hlthcare | |||
| 11617751 | 2030-07-17 | DP | U-1, U-3572, U-3573, U-3574 |
| 8617597 | 2030-02-08 | DP | |
| Ethinyl Estradiol / Levonorgestrel, Quartette, Teva Branded Pharm | |||
| 8415332 | 2029-03-11 | DP | |
| 8450299 | 2025-10-07 | U-1 | |
| Ethinyl Estradiol / Norethindrone Acetate, Lo Loestrin Fe, Apil | |||
| 7704984 | 2029-02-02 | U-1, U-1090 | |
| Ethinyl Estradiol / Levonorgestrel, Loseasonique, Teva Branded Pharm | |||
| 7855190 | 2028-12-05 | U-1 | |
| 7858605 | 2023-06-23 | DP | |
| 7615545 | 2023-06-15 | U-1 | |
| Ethinyl Estradiol / Levonorgestrel, Twirla, Agile | |||
| 8246978 | 2028-08-26 | DP | |
| 8747888 | 2028-07-10 | DP | |
| 9050348 | 2028-07-10 | DP | |
| Ethinyl Estradiol / Levonorgestrel, Balcoltra, Avion Pharms | |||
| 7838042 | 2027-06-01 | DP | U-3251 |
| Ethinyl Estradiol / Levonorgestrel, Seasonique, Teva Branded Pharm | |||
| 7320969 | 2024-01-30 | U-828 | |

Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Contraception | D003267 | — | — | 17 | 15 | 47 | 21 | 22 | 120 |
| Healthy volunteers/patients | — | — | — | 67 | — | 6 | 1 | 1 | 75 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 4 | 4 | 5 | 13 | 13 | 38 |
| Dysmenorrhea | D004412 | — | N94.6 | 1 | 4 | 13 | 4 | 1 | 20 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 10 | 3 | — | 1 | 4 | 18 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | 3 | 6 | 7 | 5 | 18 |
| Syndrome | D013577 | — | — | 1 | 4 | 6 | 2 | 4 | 17 |
| Infertility | D007246 | EFO_0000545 | — | 3 | 1 | — | 4 | 6 | 13 |
| Pelvic pain | D017699 | — | — | — | 1 | 2 | 5 | 4 | 12 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | — | 5 | 2 | 4 | 11 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | — | 4 | 2 | — | — | 4 |
| Headache | D006261 | — | R51 | — | 1 | 1 | — | 2 | 4 |
| Turner syndrome | D014424 | Orphanet_881 | Q96 | — | 2 | 2 | — | — | 4 |
| Gonadal dysgenesis | D006059 | — | — | — | 2 | 2 | — | — | 4 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 2 | — | 1 | — | — | 3 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | 1 | — | 1 | 3 |
| Neural tube defects | D009436 | — | Q00.0 | — | — | 3 | — | — | 3 |
| Premature menopause | D008594 | — | E28.31 | — | — | 1 | — | 1 | 2 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | 1 | — | 1 | 2 |
| Anorexia | D000855 | — | R63.0 | — | 2 | 2 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metrorrhagia | D008796 | — | N92.1 | — | 4 | — | — | 4 | 8 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | 3 | 4 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | 2 | — | — | — | 3 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 1 | — | — | 1 | 3 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | — | — | 2 | 3 |
| Feeding and eating disorders | D001068 | — | F50 | — | 2 | — | — | — | 2 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | — | 2 |
| Hemostasis | D006487 | — | — | — | 2 | — | — | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 1 | — | — | — | 2 |
| Ovarian diseases | D010049 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 11 | — | — | — | — | 11 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 10 | — | — | — | — | 10 |
| Therapeutic equivalency | D013810 | — | — | 9 | — | — | — | 1 | 10 |
| Hepatitis c | D006526 | — | B19.2 | 7 | — | — | — | — | 7 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 5 | — | — | — | 1 | 6 |
| Overweight | D050177 | — | E66.3 | 4 | — | — | — | 2 | 6 |
| Drug interactions | D004347 | — | — | 6 | — | — | — | — | 6 |
| Infections | D007239 | EFO_0000544 | — | 5 | — | — | — | — | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 4 | — | — | — | — | 4 |
| Neoplasms | D009369 | — | C80 | 4 | — | — | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 5 | 5 |
| Thromboembolism | D013923 | — | — | — | — | — | — | 5 | 5 |
| Gingivitis | D005891 | — | K05.10 | — | — | — | — | 3 | 3 |
| Venous thrombosis | D020246 | — | I82.40 | — | — | — | — | 2 | 2 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 2 | 2 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | — | 2 | 2 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 2 | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 2 | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 1 | 1 |
| Drug common name | Ethinyl estradiol |
| INN | ethinylestradiol |
| Description | 17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid. It is functionally related to a 17beta-estradiol and an estradiol. |
| Classification | Small molecule |
| Drug class | estrogens |
| Image (chem structure or protein) | ![]() |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C |
| PDB | — |
| CAS-ID | 57-63-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL691 |
| ChEBI ID | 4903 |
| PubChem CID | 5991 |
| DrugBank | DB00977 |
| UNII ID | 423D2T571U (ChemIDplus, GSRS) |




































































