Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TWIRLA | Agile Therapeutics | N-204017 RX | 2020-02-14 | 1 products, RLD, RS |
BALCOLTRA | Avion Pharmaceuticals | N-208612 RX | 2018-01-09 | 1 products, RLD, RS |
TYBLUME | Exeltis | N-209405 RX | 2020-03-30 | 1 products, RLD, RS |
LOSEASONIQUE | Teva | N-022262 RX | 2008-10-24 | 1 products |
QUARTETTE | Teva | N-204061 RX | 2013-03-28 | 1 products, RLD, RS |
SEASONALE | Teva | N-021544 RX | 2003-09-05 | 1 products, RLD, RS |
SEASONIQUE | Teva | N-021840 RX | 2006-05-25 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CYCLESSA | Aspen Global | N-021090 RX | 2000-12-20 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TRI-NORINYL 28-DAY | Dr Reddys Laboratories | N-018977 RX | 1984-04-13 | 1 products, RLD, RS |
NORETHINDRONE AND ETHINYL ESTRADIOL AND FERROUS FUMARATE | Teva | N-022573 RX | 2010-12-22 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ORTHO CYCLEN-21 | Johnson & Johnson | N-019653 DISCN | 1989-12-29 | 1 products |
ORTHO CYCLEN-28 | Johnson & Johnson | N-019653 DISCN | 1989-12-29 | 1 products, RLD |
ORTHO TRI-CYCLEN | Johnson & Johnson | N-019697 DISCN | 1992-07-03 | 2 products |
ORTHO TRI-CYCLEN LO | Johnson & Johnson | N-021241 DISCN | 2002-08-22 | 1 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ORTHO EVRA | Johnson & Johnson | N-021180 DISCN | 2001-11-20 | 1 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
LYNORAL | Organon | N-005490 DISCN | 1982-01-01 | 2 products |
FEMINONE | Pharmacia & Upjohn | N-016649 DISCN | 1982-01-01 | 1 products |
ESTINYL | Merck & Co | N-005292 DISCN | 1982-01-01 | 3 products |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
DEMULEN 1/50-21 | G.D. Searle | N-016927 DISCN | 1982-01-01 | 1 products |
DEMULEN 1/50-28 | G.D. Searle | N-016936 DISCN | 1982-01-01 | 1 products |
DEMULEN 1/35-28 | G.D. Searle | N-018160 DISCN | 1982-01-01 | 1 products |
DEMULEN 1/35-21 | G.D. Searle | N-018168 DISCN | 1982-01-01 | 1 products |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ANNOVERA | Mayne Group | N-209627 RX | 2018-08-10 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
affodel | ANDA | 2024-04-22 |
afirmelle | ANDA | 2024-09-19 |
altavera | ANDA | 2023-03-02 |
alyacen 1/35 | ANDA | 2024-05-07 |
alyacen 1/35 alyacen 7/7/7 | ANDA | 2017-09-08 |
alyacen 7/7/7 | ANDA | 2023-06-07 |
amethia | ANDA | 2024-03-01 |
amethyst | ANDA | 2022-01-31 |
annovera | New Drug Application | 2024-08-08 |
apri | ANDA | 2024-06-12 |
Expiration | Code | ||
---|---|---|---|
ETHINYL ESTRADIOL / SEGESTERONE ACETATE, ANNOVERA, MAYNE PHARMA | |||
2023-08-10 | NCE | ||
ETHINYL ESTRADIOL / LEVONORGESTREL, TYBLUME, EXELTIS USA INC | |||
2023-03-30 | NDF | ||
ETHINYL ESTRADIOL / LEVONORGESTREL, TWIRLA, AGILE | |||
2023-02-14 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Ethinyl Estradiol / Segesterone Acetate, Annovera, Mayne Pharma | |||
10918649 | 2039-06-21 | DP | |
10925882 | 2039-06-21 | DP | |
10940157 | 2039-06-21 | DP | |
11529308 | 2039-06-21 | DP | |
10632066 | 2039-02-01 | U-2786, U-2787 | |
10765628 | 2039-02-01 | U-2786, U-2787 | |
10780047 | 2039-02-01 | U-2786, U-2787 | |
Drospirenone / Ethinyl Estradiol / Levomefolate Calcium, Beyaz, Bayer Hlthcare | |||
11617751 | 2030-07-17 | DP | U-1, U-3572, U-3573, U-3574 |
8617597 | 2030-02-08 | DP | |
Ethinyl Estradiol / Levonorgestrel, Quartette, Teva Branded Pharm | |||
8415332 | 2029-03-11 | DP | |
8450299 | 2025-10-07 | U-1 | |
Ethinyl Estradiol / Norethindrone Acetate, Lo Loestrin Fe, Apil | |||
7704984 | 2029-02-02 | U-1, U-1090 | |
Ethinyl Estradiol / Levonorgestrel, Loseasonique, Teva Branded Pharm | |||
7855190 | 2028-12-05 | U-1 | |
7858605 | 2023-06-23 | DP | |
7615545 | 2023-06-15 | U-1 | |
Ethinyl Estradiol / Levonorgestrel, Twirla, Agile | |||
8246978 | 2028-08-26 | DP | |
8747888 | 2028-07-10 | DP | |
9050348 | 2028-07-10 | DP | |
Ethinyl Estradiol / Levonorgestrel, Balcoltra, Avion Pharms | |||
7838042 | 2027-06-01 | DP | U-3251 |
Ethinyl Estradiol / Levonorgestrel, Seasonique, Teva Branded Pharm | |||
7320969 | 2024-01-30 | U-828 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 232 | 1 | 6 | 6 | 6 | 251 |
Contraception | D003267 | — | — | 18 | 16 | 47 | 21 | 29 | 129 |
Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 8 | 28 | 21 | 6 | 9 | 63 |
Syndrome | D013577 | — | — | 2 | 5 | 11 | 9 | 14 | 41 |
Infections | D007239 | EFO_0000544 | — | 9 | 2 | 14 | 6 | 7 | 38 |
Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 3 | 2 | 6 | 13 | 11 | 35 |
Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | 1 | 19 | 17 | 1 | 2 | 33 |
Pneumonia | D011014 | EFO_0003106 | — | — | 5 | 14 | 5 | 7 | 31 |
Cataract | D002386 | HP_0000518 | H26.9 | 3 | 3 | 3 | 19 | 4 | 30 |
Hiv infections | D015658 | EFO_0000764 | B20 | 15 | 2 | 1 | 1 | 6 | 25 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hepatitis c | D006526 | — | B19.2 | 10 | — | 1 | — | 3 | 14 |
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 9 | — | 1 | — | 1 | 11 |
Neoplasms | D009369 | — | C80 | 6 | 1 | 1 | — | 2 | 10 |
Keratitis | D007634 | HP_0000491 | H16 | — | 1 | 7 | — | 2 | 9 |
Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 2 | 6 | — | — | 8 |
Hepatitis | D006505 | HP_0012115 | K75.9 | 3 | — | 1 | — | 4 | 8 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 4 | — | 1 | 7 |
Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 4 | — | 1 | — | 2 | 7 |
Fatty liver | D005234 | EFO_0003934 | — | 4 | — | 1 | — | 2 | 7 |
Hypertension | D006973 | EFO_0000537 | I10 | 4 | 1 | 1 | — | — | 6 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pharmacokinetics | D010599 | — | — | 18 | 1 | — | — | 2 | 21 |
Parkinson disease | D010300 | EFO_0002508 | G20 | 3 | 1 | — | — | 1 | 5 |
Benign familial pemphigus | D016506 | — | Q82.8 | 1 | 1 | — | — | 3 | 5 |
Pharmacological phenomena | D000069437 | — | — | 3 | 1 | — | — | — | 4 |
Depression | D003863 | — | F33.9 | — | 1 | — | — | 2 | 3 |
Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | — | — | 2 |
Hemostasis | D006487 | — | — | — | 2 | — | — | — | 2 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | 1 | — | — | — | 2 |
Osteoporosis | D010024 | HP_0000939 | M81.0 | — | 1 | — | — | 1 | 2 |
Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 1 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 12 | — | — | — | 1 | 13 |
Therapeutic equivalency | D013810 | — | — | 11 | — | — | — | 1 | 12 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 9 | — | — | — | — | 9 |
Long qt syndrome | D008133 | HP_0001657 | I45.81 | 4 | — | — | — | 3 | 7 |
Heart failure | D006333 | HP_0001635 | I50 | 2 | — | — | — | 5 | 7 |
Schizophrenia | D012559 | EFO_0000692 | F20 | 5 | — | — | — | — | 5 |
Drug interactions | D004347 | — | — | 5 | — | — | — | — | 5 |
Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 2 | — | — | — | 2 | 4 |
Coronary artery disease | D003324 | — | I25.1 | 2 | — | — | — | 2 | 4 |
Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 2 | — | — | — | 2 | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | — | 6 | 6 |
Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 5 | 5 |
Thromboembolism | D013923 | HP_0001907 | — | — | — | — | — | 5 | 5 |
Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | — | 4 | 4 |
Bradycardia | D001919 | HP_0001662 | R00.1 | — | — | — | — | 4 | 4 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 3 | 3 |
Pathologic dilatation | D004108 | — | — | — | — | — | — | 3 | 3 |
Regeneration | D012038 | — | — | — | — | — | — | 3 | 3 |
Gingivitis | D005891 | HP_0000230 | K05.10 | — | — | — | — | 3 | 3 |
Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | — | — | 2 | 2 |
Drug common name | Ethinyl estradiol |
INN | ethinylestradiol |
Description | 17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid. It is functionally related to a 17beta-estradiol and an estradiol. |
Classification | Small molecule |
Drug class | estrogens |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C |
PDB | — |
CAS-ID | 57-63-6 |
RxCUI | — |
ChEMBL ID | CHEMBL691 |
ChEBI ID | 4903 |
PubChem CID | 5991 |
DrugBank | DB00977 |
UNII ID | 423D2T571U (ChemIDplus, GSRS) |