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Drug ReportsEthinyl estradiol
Loestrin fe 1/20, Evra(ethinyl estradiol)
/ Ethinyl Estradiol, Afirmelle, Altavera, Alyacen, Annovera, Aranelle, Ashlyna, Aurovela, Aviane, Ayuna, Balcoltra, Balziva, Bekyree, Beyaz, Blisovi, Briellyn, Cryselle, Cyclessa, Cyonanz, Dasetta, Daysee, Dolishale, Drospirenone / Ethinyl Estradiol, Drospirenone / Ethinyl Estradiol /, Elinest, Eluryng, Enpresse, Enskyce, Estarylla, Estinyl, Ethinyl Estradiol /, Evra, Falmina, Fe, Finzala, Fyavolv, Gemmily, Gildagia, Gildess, Hailey, Iclevia, Introvale, Jaimiess, Junel, Kalliga, Kariva, Kelnor, Larin, Leribane, Lessina, Levonest, Levora, Lo Fe, Lo Simpesse, Lo Sprintec, Lynoral, Malmorede, Marlissa, Melamisa, Merzee, Mibelas, Mili, Minzoya, Mono-linyah, Myzilra, Nikki, Norlestrin, Nortrel, Nuvaring, Nylia, Onsura, Oshih, Philith, Pimtrea, Portia, Quartette, Quasense, Safyral, Seasonale, Seasonique, Setlakin, Simliya, Simpesse, Sprintec, Syeda, Taytulla, Tri-estarylla, Tri-linyah, Tri-mili, Tri-norinyl, Trivora, Turqoz, Twirla, Tyblume, Tydemy, Velivet, Vienva, Viorele, Volnea, Wera, Xulane, Yaela, Yasmin, Yaz, Zovia, Zumandimine (ethinyl estradiol) is a small molecule pharmaceutical. Ethinyl estradiol was first approved as Lynoral on 1982-01-01. It is used to treat breast neoplasms, hot flashes, hypogonadism, menorrhagia, and premature menopause amongst others in the USA. It has been approved in Europe to treat contraception. The pharmaceutical is active against estrogen receptor. In addition, it is known to target estrogen receptor beta.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
therapeuticsD013812
reproductive and urinary physiological phenomenaD012101
Trade Name
FDA
EMA
Combinations
Afirmelle, Altavera, Alyacen, Annovera, Aranelle, Ashlyna, Aurovela, Averi, Aviane, Ayuna, Balcoltra, Balziva, Bekyree, Beyaz, Blisovi, Briellyn, Chabelina fe, Cryselle, Cyclessa, Cyonanz, Dasetta, Daysee, Desogestrel ethinyl estradiol, Dolishale, Drospirenone ethinyl estradiol, Drospirenone, ethinyl estradiol levomefolate, Elinest, Eluryng, Enilloring, Enpresse, Enskyce, Estarylla, Ethinyl estradiol norelgestromin, Ethinyl estradiol; etonogestrel, Ethynodiol ethinyl estradiol, Falmina, Femlyv, Finzala, Fyavolv, Gemmily, Gildagia, Gildess, Hailey, Haloette, Iclevia, Introvale, Isibloom, Jaimiess, Junel, Kaitlib fe, Kalliga, Kariva, Kelnor, Kurvelo, Larin, Leribane, Lessina, Levonest, Levonorgestrel ethinyl estradiol, Levonorgestrel ethinyl estradiol ethinyl estradiol, Levonorgestrel ethinyl estradiol ferrous, Levora, Lo loestrin fe, Lo simpesse, Lo-malmorede, Lo-zumandimine, Loryna, Loseasonique, Low-ogestrel, Malmorede, Marlissa, Melamisa, Merzee, Mibelas, Mili, Minzoya, Mono-linyah, Myzilra, Nexesta fe, Nikki, Norethindrone ethinyl estradiol, Norethindrone ethinyl estradiol (), Norethindrone ethinyl estradiol ferrous, Norgestimate ethinyl estradiol, Nortrel, Nuvaring, Nylia, Onsura, Philith, Pimtrea, Portia, Previfem, Quartette, Quasense, Safyral, Seasonale, Seasonique, Setlakin, Simliya, Simpesse, Sprintec, Syeda, Taytulla, Tri lo sprintec, Tri-estarylla, Tri-legest fe, Tri-linyah, Tri-lo-estarylla, Tri-lo-linyah, Tri-lo-mili, Tri-mili, Tri-norinyl, Tri-sprintec, Trivora, Turqoz, Twirla, Tyblume, Tydemy, Velivet, Vienva, Viorele, Volnea, Vyfemla, Wera, Xulane, Yaela, Yasmin, Yaz, Zovia, Zumandimine (discontinued: Alesse, Aviane, Balziva, Brevicon, Cerinta, Cyclafem, Demulen, Desogen, Desogestrel ethinyl estradiol, Drospirenone ethinyl estradiol, Elifemme, Emoquette, Enpresse, Estrostep fe, Fayosim, Femcon fe, Femhrt, Gencept, Gildess, Kemeya, Kimidess, Kyra, Lessina, Levlite, Levonorgestrel ethinyl estradiol, Levonorgestrel ethinyl estradiol ethinyl estradiol, Levora, Lo minastrin fe, Lo/ovral, Loestrin, Loestrin 21, Low-ogestrel, Lybrel, Microgestin, Minastrin, Mircette, Modicon, Norcept, Nordette, Norethin, Norethindrone ethinyl estradiol, Norethindrone ethinyl estradiol (), Norethindrone ethinyl estradiol ethinyl estradiol ferrous, Norethindrone ethinyl estradiol ferrous, Norgestimate ethinyl estradiol, Norgestrel ethinyl estradiol, Norinyl 1+35, Norlestrin, Norlestrin 21, Norquest fe, Nortrel, Ogestrel, Orsythia, Ortho cyclen, Ortho evra, Ortho tri-cyclen, Ortho tri-cyclen lo, Ortho-cept, Ortho-novum, Oshih, Ovcon, Ovral, Pirmella, Portia, Preven emergency contraceptive, Rhuzdah, Sylevia, Tri-legest, Tri-norinyl, Tri-previfem, Triphasil, Trivora, Veraring, Zovia)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ethinyl estradiol
+
Norethindrone acetate
Tradename
Company
Number
Date
Products
LO LOESTRIN FEAllerganN-022501 RX2010-10-21
1 products, RLD, RS
TAYTULLAAllerganN-204426 RX2013-04-19
1 products, RLD, RS
FEMLYVMillicent PharmaN-218718 RX2024-07-22
1 products, RLD, RS
Show 13 discontinued
Ethinyl estradiol
+
Levonorgestrel
Tradename
Company
Number
Date
Products
TWIRLAAgile TherapeuticsN-204017 RX2020-02-14
1 products, RLD, RS
BALCOLTRAAvion PharmaceuticalsN-208612 RX2018-01-09
1 products, RLD, RS
TYBLUMEExeltisN-209405 RX2020-03-30
1 products, RLD, RS
LOSEASONIQUETevaN-022262 RX2008-10-24
1 products
QUARTETTETevaN-204061 RX2013-03-28
1 products, RLD, RS
SEASONALETevaN-021544 RX2003-09-05
1 products, RLD, RS
SEASONIQUETevaN-021840 RX2006-05-25
1 products, RLD, RS
Show 8 discontinued
Desogestrel
+
Ethinyl estradiol
Tradename
Company
Number
Date
Products
CYCLESSAAspen GlobalN-021090 RX2000-12-20
1 products, RLD, RS
Show 3 discontinued
Ethinyl estradiol
+
Norethindrone
Tradename
Company
Number
Date
Products
TRI-NORINYL 28-DAYDr Reddys LaboratoriesN-018977 RX1984-04-13
1 products, RLD, RS
Show 21 discontinued
Ethinyl estradiol
+
Norgestimate
Tradename
Company
Number
Date
Products
ORTHO CYCLEN-21Johnson & JohnsonN-019653 DISCN1989-12-29
1 products
ORTHO CYCLEN-28Johnson & JohnsonN-019653 DISCN1989-12-29
1 products, RLD
ORTHO TRI-CYCLENJohnson & JohnsonN-019697 DISCN1992-07-03
2 products
ORTHO TRI-CYCLEN LOJohnson & JohnsonN-021241 DISCN2002-08-22
1 products, RLD
Hide discontinued
Ethinyl estradiol
+
Norelgestromin
Tradename
Company
Number
Date
Products
ORTHO EVRAJohnson & JohnsonN-021180 DISCN2001-11-20
1 products, RLD
Hide discontinued
Ethinyl estradiol
Tradename
Company
Number
Date
Products
LYNORALOrganonN-005490 DISCN1982-01-01
2 products
FEMINONEPharmacia & UpjohnN-016649 DISCN1982-01-01
1 products
ESTINYLMerck & CoN-005292 DISCN1982-01-01
3 products
Hide discontinued
Ethinyl estradiol
+
Etonogestrel
Tradename
Company
Number
Date
Products
NUVARINGOrganonN-021187 RX2001-10-03
1 products, RLD, RS
Ethinyl estradiol
+
Norgestrel
Tradename
Company
Number
Date
Products
LO/OVRALCadence PharmaceuticalsN-017612 DISCN1982-01-01
1 products, RLD
LO/OVRAL-28WyethN-017802 DISCN1982-01-01
1 products, RLD
OVRALWyethN-016672 DISCN1982-01-01
1 products
OVRAL-28WyethN-016806 DISCN1982-01-01
1 products
Hide discontinued
Drospirenone
+
Ethinyl estradiol
+
Levomefolate calcium
Tradename
Company
Number
Date
Products
BEYAZBayerN-022532 RX2010-09-24
1 products, RLD, RS
SAFYRALBayerN-022574 RX2010-12-16
1 products, RLD, RS
Drospirenone
+
Ethinyl estradiol
Tradename
Company
Number
Date
Products
YASMINBayerN-021098 RX2001-05-11
1 products, RLD, RS
YAZBayerN-021676 RX2006-03-16
1 products, RLD, RS
Ethinyl estradiol
+
Ferrous fumarate
+
Norethindrone acetate
Tradename
Company
Number
Date
Products
NORLESTRIN FE 1/50PfizerN-016766 DISCN1982-01-01
1 products
NORLESTRIN FE 2.5/50PfizerN-016854 DISCN1982-01-01
1 products
Hide discontinued
Ethinyl estradiol
+
Ferrous fumarate
+
Norethindrone
Tradename
Company
Number
Date
Products
NORQUEST FEPfizerN-018926 DISCN1986-07-18
1 products
Hide discontinued
Ethinyl estradiol
+
Ethynodiol diacetate
Tradename
Company
Number
Date
Products
DEMULEN 1/50-21G.D. SearleN-016927 DISCN1982-01-01
1 products
DEMULEN 1/50-28G.D. SearleN-016936 DISCN1982-01-01
1 products
DEMULEN 1/35-28G.D. SearleN-018160 DISCN1982-01-01
1 products
DEMULEN 1/35-21G.D. SearleN-018168 DISCN1982-01-01
1 products
Hide discontinued
Ethinyl estradiol
+
Segesterone acetate
Tradename
Company
Number
Date
Products
ANNOVERAMayne GroupN-209627 RX2018-08-10
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
afirmelleANDA2025-08-01
altaveraANDA2023-03-02
alyacen 1/35ANDA2024-05-07
alyacen 1/35 alyacen 7/7/7ANDA2017-09-08
alyacen 7/7/7ANDA2023-06-07
amethiaANDA2024-03-01
amethystANDA2022-01-31
annoveraNew Drug Application2025-04-23
apriANDA2024-06-12
aranelleANDA2023-01-31
Show 227 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
prostatic neoplasms—D011471C61
breast neoplasmsEFO_0003869D001943C50
menorrhagiaEFO_0003945D008595N92.0
primary ovarian insufficiencyEFO_0004266D016649E28.3
hot flashes—D019584—
hypogonadism—D007006E23.0
premature menopause—D008594E28.31
acne vulgarisEFO_0003894D000152L70
endometriosisEFO_0001065D004715N80
endometrial hyperplasia—D004714N85.0
Show 6 more
Agency Specific
FDA
EMA
Expiration
Code
ETHINYL ESTRADIOL / SEGESTERONE ACETATE, ANNOVERA, MAYNE PHARMA
2023-08-10NCE
ETHINYL ESTRADIOL / LEVONORGESTREL, TYBLUME, EXELTIS USA INC
2023-03-30NDF
ETHINYL ESTRADIOL / LEVONORGESTREL, TWIRLA, AGILE
2023-02-14NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Ethinyl Estradiol / Segesterone Acetate, Annovera, Mayne Pharma
109186492039-06-21DP
109258822039-06-21DP
109401572039-06-21DP
115293082039-06-21DP
106320662039-02-01U-2786, U-2787
107656282039-02-01U-2786, U-2787
107800472039-02-01U-2786, U-2787
Drospirenone / Ethinyl Estradiol / Levomefolate Calcium, Beyaz, Bayer Hlthcare
116177512030-07-17DPU-1, U-3572, U-3573, U-3574
86175972030-02-08DP
Ethinyl Estradiol / Levonorgestrel, Quartette, Teva Branded Pharm
84153322029-03-11DP
84502992025-10-07U-1
Ethinyl Estradiol / Norethindrone Acetate, Lo Loestrin Fe, Apil
77049842029-02-02U-1, U-1090
Ethinyl Estradiol / Levonorgestrel, Loseasonique, Teva Branded Pharm
78551902028-12-05U-1
78586052023-06-23DP
76155452023-06-15U-1
Ethinyl Estradiol / Levonorgestrel, Twirla, Agile
82469782028-08-26DP
87478882028-07-10DP
90503482028-07-10DP
Ethinyl Estradiol / Levonorgestrel, Balcoltra, Avion Pharms
78380422027-06-01DPU-3251
Ethinyl Estradiol / Levonorgestrel, Seasonique, Teva Branded Pharm
73209692024-01-30U-828
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA01: Etynodiol and ethinylestradiol
— G03AA02: Quingestanol and ethinylestradiol
— G03AA03: Lynestrenol and ethinylestradiol
— G03AA04: Megestrol and ethinylestradiol
— G03AA05: Norethisterone and ethinylestradiol
— G03AA06: Norgestrel and ethinylestradiol
— G03AA07: Levonorgestrel and ethinylestradiol
— G03AA08: Medroxyprogesterone and ethinylestradiol
— G03AA09: Desogestrel and ethinylestradiol
— G03AA10: Gestodene and ethinylestradiol
— G03AA11: Norgestimate and ethinylestradiol
— G03AA12: Drospirenone and ethinylestradiol
— G03AA13: Norelgestromin and ethinylestradiol
— G03AA15: Chlormadinone and ethinylestradiol
— G03AA16: Dienogest and ethinylestradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB01: Megestrol and ethinylestradiol
— G03AB02: Lynestrenol and ethinylestradiol
— G03AB03: Levonorgestrel and ethinylestradiol
— G03AB04: Norethisterone and ethinylestradiol
— G03AB05: Desogestrel and ethinylestradiol
— G03AB06: Gestodene and ethinylestradiol
— G03AB07: Chlormadinone and ethinylestradiol
— G03AB09: Norgestimate and ethinylestradiol
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CA: Natural and semisynthetic estrogens, plain
— G03CA01: Ethinylestradiol
L: Antineoplastic and immunomodulating agents
— L02: Endocrine therapy antineoplastic and immunomodulating agents
— L02A: Hormones and related agents
— L02AA: Estrogens, endocrine therapy drugs
— L02AA03: Ethinylestradiol
HCPCS
Code
Description
J7294
Segesterone acetate and ethinyl estradiol 0.15mg, 0.013mg per 24 hours; yearly vaginal system, each
J7295
Ethinyl estradiol and etonogestrel 0.015mg, 0.12mg per 24 hours; monthly vaginal ring, each
Clinical
Clinical Trials
517 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2—1——3
ContraceptionD003267————2——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vision disordersD014786—H53.11—1———1
Ovulation inhibitionD034445———1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEthinyl estradiol
INNethinylestradiol
Description
17alpha-ethynylestradiol is a 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration. It has a role as a xenoestrogen. It is a 17-hydroxy steroid, a terminal acetylenic compound and a 3-hydroxy steroid. It is functionally related to a 17beta-estradiol and an estradiol.
Classification
Small molecule
Drug classestrogens
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C
Identifiers
PDB—
CAS-ID57-63-6
RxCUI—
ChEMBL IDCHEMBL691
ChEBI ID4903
PubChem CID5991
DrugBankDB00977
UNII ID423D2T571U (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ESR2
ESR2
NR1I2
NR1I2
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
2100
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Q92731
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Nuvaring – Organon
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Nuvaring – Merck & Co
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Loestrin – Allergan
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Annovera – TherapeuticsMD
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Estimated US medical usage
Ethinyl estradiol
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Desogestrel
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Drospirenone
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Drospirenone
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Levomefolic acid
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Ethinyl estradiol
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Ethinyl estradiol
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Ethynodiol
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Ethinyl estradiol
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Etonogestrel
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Levonorgestrel
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Ethinyl estradiol
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Norelgestromin
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Ethinyl estradiol
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Norethindrone
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Ethinyl estradiol
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Norgestimate
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Ethinyl estradiol
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Norgestrel
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,265 documents
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Safety
Black-box Warning
Black-box warning for: Altavera, Amethia, Annovera, Ashlyna, Aurovela 1.5/30, Aurovela 24 fe, Averi, Ayuna, Balcoltra, Bekyree, Beyaz, Blisovi 24 fe, Blisovi fe 1.5/30, Blisovi fe 1/20, Camrese, Camrese lo, Camreselo, Charlotte 24fe, Chateal eq, Cryselle, Cyclafem 1/35, Cyclafem 7/7/7, Cyonanz, Cyred eq, Dasetta 1/35, Dasetta 7/7/7, Daysee, Desogestrel and ethinyl estradiol, Drospirenone and ethinyl estradiol, Drospirenone, ethinyl estradiol and levomefolate calcium and levomefolate calcium, Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium, Elinest, Eluryng, Enilloring, Enskyce, Estarylla, Etonogestrel and ethinyl estradiol, Etonogestrel and ethinyl estradiol vaginal, Etonogestrel and ethinyl estradiol vaginal ring, Etonogestrel/ethinyl estradiol, Feirza 1.5/30 tm, Femynor, Finzala, Fyavolv, Galbriela, Gemmily, Hailey 1.5/30, Hailey 24 fe, Hailey fe 1.5/30, Hailey fe 1/20, Haloette, Iclevia, Introvale, Isibloom, Jaimiess, Jasmiel, Jinteli, Jolessa, Joyeaux, Juleber, Junel, Junel fe, Junel fe 1/20, Junel fe 28 day, Kaitlib fe, Kalliga, Kariva, Kurvelo, Larin 1.5/30, Larin 1/20, Larin 24 fe, Larin fe 1/20, Layolis fe, Levonorgestrel and ethinyl estradiol, Levonorgestrel and ethinyl estradiol and ethinyl estradiol, Levonorgestrel/ethinyl estradiol and ethinyl estradiol, Levora, Lo loestrin fe, Lo simpesse, Lo-zumandimine, Loestrin, Loestrin 24 fe, Lojaimiess, Loryna, Loseasonique, Low-ogestrel, Luizza 1/20, Marlissa, Melodetta 24 fe, Merzee, Mibelas 24 fe, Microgestin 1.5/30, Microgestin 1/20, Microgestin 24 fe, Mili, Minzoya, Mono-linyah, Mononessa, Myzilra, Necon, Nexesta fe, Nikki, Norelgestromin and ethinyl estradiol, Norethindrone acetate and ethinyl estradiol, Norethindrone acetate and ethinyl estradiol and ferrous fumarate, Norethindrone acetate and ethinyl estradiol, and ferrous fumarate, Norethindrone and ethinyl estradiol, Norethindrone and ethinyl estradiol and ferrous fumarate, Norgestimate and ethinyl estradiol, Nuvaring, Nylia 1/35, Nylia 7/7/7, Nymyo, Ocella, Ortho tri-cyclen lo, Oshih, Pimtrea, Portia, Previfem, Rivelsa, Rosyrah, Safyral, Seasonique, Setlakin, Simliya, Simpesse, Sprintec, Syeda, Tarina 24 fe, Taysofy, Taytulla, Tri femynor, Tri-estarylla, Tri-legest fe, Tri-linyah, Tri-lo- estarylla, Tri-lo-marzia, Tri-lo-mili, Tri-lo-sprintec, Tri-mili, Tri-nymyo, Tri-sprintec, Tri-vylibra, Tri-vylibra lo, Trinessa, Turqoz, Tyblume, Tydemy, Vestura, Viorele, Vylibra, Wera, Wymzya fe, Xarah fe, Xelria fe, Xulane, Yasmin, Yaz, Zafemy, Zarah, Zenchent fe, Zumandimine
Adverse Events
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